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desvenlafaxine will improve the level or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Observe. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, four hundred mg) reduce the CYP2D6 substrate dose by around 50%; no dosage adjustment required with desvenlafaxine doses seven consecutive times immedia